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Accession IconE-MEXP-2098

Transcription profiling by array of rat hear after injury followed by treatment with saline, urocortin I, urocortin II or tempol

Organism Icon Rattus norvegicus
Sample Icon 15 Downloadable Samples
Technology Badge Icon Affymetrix Rat Expression 230A Array (rae230a)

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Description
The transcriptional effects of urocortin I, urocortin II and tempol were compared to saline treatment in a rat model of in vivo coronary artery occlusion model of ischaemia/reperfusion injury of 25 min ischaemia and 2 hr reperfusion. <br></br>The treatment groups were as follows (i) sham operation or LAD occlusion with infusion of (ii) saline, (iii) 15 ?g/kg Ucn I, (iv) 15 ?g/kg Ucn II and (v) 100 mg/kg tempo infused just prior to reperfusionl.<br></br>Following 2 hr reperfusion the left ventricle was removed, snap frozen, followed by RNA extraction.
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15
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