Expression data from myeloma cell lines treated with 500 nM pristimerin or DMSO vehicle alone for 4 hours

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GSE14011

Homo sapiens

4 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

As multiple myeloma tumors universally dysregulate cyclin D genes we conducted high-throughput chemical library screens for compounds that induce suppression of cyclin D2. The top-ranked compound was a natural triterpenoid, pristimerin.

PubMed ID

19096011

Publication Title

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.

Total Samples

Submitter’s Institution

Mayo Clinic

Authors

Tiedemann RE, Schmidt J, Keats JJ, Shi CX, Zhu YX, Palmer SE, Mao X, Schimmer AD, Stewart AK

Source Repository

Gene Expression Omnibus (GEO)

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