Mammary tumors in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5

GSE15119

Mus musculus

16 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

Stat5 is a latent transcription factor that regulates essential growth and survival functions in normal cells. Constitutive activity of Stat5 and the involvement of its C-terminally truncated variant have been implicated in blood cell malignancies and mammary or breast cancer.

PubMed ID

20717961

Publication Title

Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation.

Total Samples

Submitter’s Institution

The Volcani Center

Authors

Eilon T, Barash I

Source Repository

Gene Expression Omnibus (GEO)

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