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Accession IconGSE19601

Gene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b

Organism Icon Mus musculus
Sample Icon 8 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description
TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the induction of apoptosis, it is not well elucidated whether the each effect of TGF-b on T cells is dependent on Smad signaling or Smad-independent other signaling pathways.
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Total Samples
8
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Samples

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Additional Metadata
CD4T_S23h_TGF(+)
cd4+ t cells
with tgf-b for 24hr
CD4T_S3_TGF(-)
cd4+ t cells
without tgf-b for 24hr
CD4T_S2_TGF(-)
cd4+ t cells
without tgf-b for 24hr
CD4T_S2_TGF(+)
cd4+ t cells
with tgf-b for 24hr
CD4T_S3_TGF(+)
cd4+ t cells
with tgf-b for 24hr
CD4T_WT_TGF(+)
cd4+ t cells
with tgf-b for 24hr
CD4T_S23h_TGF(-)
cd4+ t cells
without tgf-b for 24hr
CD4T_WT_TGF(-)
cd4+ t cells
without tgf-b for 24hr
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