Effects of Ars2 or DGCR8 siRNA on gene expression

Ars2 is a component of the nuclear cap-binding complex that is required for cellular proliferation and contributes to microRNA biogenesis. Arrays were performed to determine the repertoire of genes that change following knock-down of Ars2. Knock-down of DGCR8 was also performed to determine which changes in Ars2 knock-down cells resulted from defects in microRNA expression.

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Gruber JJ, Olejniczak SH, Yong J, La Rocca G, Dreyfuss G, Thompson CB