The RALA pathway can maintain the proliferation of KRAS- and BRAF-mutated cancer cells

GSE39857

Homo sapiens

15 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2), Affymetrix Human Genome U133A Array (hgu133a)

Submitter Supplied Information

Description

By silencing of RALA, a downstream member of the RAS signal transduction pathway, we aimed to determine whether genes downstream of a mutated KRAS (codon 12 or 13) or a mutated BRAF can have significant functions in colorectal cancer carcinogenesis.

PubMed ID

26033452

Publication Title

Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.

Total Samples

Submitter’s Institution

Hungarian Academy of Sciences

Authors

Győrffy B, Stelniec-Klotz I, Sigler C, Kasack K, Redmer T, Qian Y, Schäfer R

Source Repository

Gene Expression Omnibus (GEO)

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