Gene expression in Early-Onset Preeclampsia Placentas and Controls

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GSE44711

Homo sapiens

16 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to elucidate the underlying biological problems that lead to early onset preeclampsia. We noted that there were DNA methylation changes in many genes of importance as well as in different genomic elements such as enhancers.

PubMed ID

23770704

Publication Title

Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.

Total Samples

Submitter’s Institution

University of British Columbia

Authors

Blair JD, Yuen RK, Lim BK, McFadden DE, von Dadelszen P, Robinson WP

Source Repository

Gene Expression Omnibus (GEO)

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