Smoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma

Both cigarette smoking and obesity have been implicated in increased risk of clear cell renal cell carcinoma (ccRCC); however, there are limited data regarding the molecular mechanisms that underlie these associations. We used a multi-stage design to identify and validate specific molecular targets that are associated with smoking or obesity-related ccRCC.

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Eckel-Passow JE, Serie DJ, Bot BM, Joseph RW, Cheville JC, Parker AS