hTERT effects in CD8 T Lymphocytes from two healthy donors

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GSE5144

Homo sapiens

20 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2), Affymetrix Human Genome U133A Array (hgu133a)

Submitter Supplied Information

Description

Expression in GFP vs. GFP/hTERT transduced CD8 T Lymphocytes from Healty Donors (HD) 1 and 2 at early and late passages. Using CD8+ T lymphocyte clones over-expressing telomerase we investigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were performed on CD8 + naive T-cell clones isolated from two different healthy individuals aged between 30 to 35 years (HD1 and HD2). T-cell cloneswere transduced to express hTERT/GFP or GFP alone.

PubMed ID

16951325

Publication Title

Mechanisms regulating the proliferative potential of human CD8+ T lymphocytes overexpressing telomerase.

Total Samples

Submitter’s Institution

Swiss Institute of Bioinformatics

Authors

Menzel O, Migliaccio M, Goldstein DR, Dahoun S, Delorenzi M, Rufer N

Source Repository

Gene Expression Omnibus (GEO)

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