Transcriptome of Irradiated Microglia

Whole brain irradiation remains important in the management of brain tumors. Although necessary for improving survival outcomes, cranial irradiation also results in cognitive decline in long-term survivors. A chronic inflammatory state characterized by microglial activation has been implicated in radiation-induced brain injury, and here we present a comprehensive transcriptional profile of irradiated microglia.

12

Li MD, Burns TC, Kumar S, Morgan AA, Sloan SA, Palmer TD