Gene expression signature of Anagrelide in megakaryocytes

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GSE60621

Homo sapiens

6 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Anagrelide is a cytoreductive agent used to lower platelet counts in essential thrombocythemia. Although the drug is known to selectively inhibit megakaryopoiesis, the molecular mechanism accounting for this activity has not been elucidated.

PubMed ID

25851510

Publication Title

The gene expression signature of anagrelide provides an insight into its mechanism of action and uncovers new regulators of megakaryopoiesis.

Total Samples

Submitter’s Institution

Cardiff Metropolitan University

Authors

Ahluwalia M, Butcher L, Donovan H, Killick-Cole C, Jones PM, Erusalimsky JD

Source Repository

Gene Expression Omnibus (GEO)

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