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Accession IconGSE60778

Central Role of ULK1 in Type I Interferon Signaling

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

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Description
We provide evidence that the Unc-51-like kinase 1 (ULK1) is phosphorylated and activated during engagement of the Type I IFN receptor. Our studies demonstrate that the function of ULK1 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
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