Effects of the insulin degrading enzyme silencing on the transcriptome of HepG2 cells

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GSE61142

Homo sapiens

12 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

Insulin degrading enzyme (IDE) is a major enzyme responsible for insulin degradation in the liver. The modulation of insulin degrading enzyme activity is hypothesized to be a link between T2DM and liver cancer. Results provide insight into role of IDE in proliferation and other cell functions.

PubMed ID

25945652

Publication Title

Modulation of insulin degrading enzyme activity and liver cell proliferation.

Total Samples

Submitter’s Institution

German Institute of Human Nutrition

Authors

Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Döcke S, Kriebel J, de las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N

Source Repository

Gene Expression Omnibus (GEO)

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