Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification

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GSE66175

Homo sapiens

479 Downloadable Samples

Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Submitter Supplied Information

Description

The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation.

PubMed ID

25960328

Publication Title

Importance of substantial weight loss for altering gene expression during cardiovascular lifestyle modification.

Total Samples

480

Submitter’s Institution

Windber Research Institute

Authors

Ellsworth DL, Mamula KA, Blackburn HL, McDyer FA, Jellema GL, van Laar R, Costantino NS, Engler RJ, Vernalis MN

Source Repository

Gene Expression Omnibus (GEO)

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