The skeletal muscle transcript profile reflects responses to inadequate protein intake in younger and older males

Inadequate protein intake initiates an accommodative response with adverse changes in skeletal muscle function and structure. mRNA level changes due to short-term inadequate dietary protein might be an early indicator of accommodation. The aims of this study were to assess the effects of dietary protein and the diet-by-age interaction on the skeletal muscle transcript profile. Self-organizing maps were used to determine expression patterns across protein trials.

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Thalacker-Mercer AE, Fleet JC, Craig BA, Campbell WW