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Accession IconGSE97910

Epistatic interaction between the lipase-encoding genes Pnpla2 (ATGL) and Lipe (HSL) causes liposarcoma in mice

Organism Icon Mus musculus
Sample Icon 72 Downloadable Samples
Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Submitter Supplied Information

Description
Liposarcoma is a poorly understood malignancy of fat cells. Lipolysis, a central pathway of adipose tissue metabolism, has been implicated in cancer. Here, we generated tissue-specific single- and combined knockout mice for the two major lipases ATGL and HSL. Notably, double knockout (DAKO) mice developed late onset liposarcoma with complete penetrance, while single knockout mice appeared normal. DAKO whole transcriptome profiles differed from those of single knockout mice, revealing an early-onset tissue-specific response that persisted until the late-onset development of liposarcoma. Cancer-associated markers Gpnmb and G0s2 were among the most highly dysregulated genes in DAKO mice and also in human liposarcomas, suggesting a potential role for these proteins as liposarcoma-specific biomarkers. Taken together, our results demonstrate a novel epistatic interaction linking lipolysis with cancer. DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset disease.
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Total Samples
72
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Samples

Show of 72 Total Samples
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ATGLAKO_brown_adipose_3months_replicate_2
3.000
brown adipose
Control_wildtype_brown_adipose_7months_replicate_2
7.000
brown adipose
HSLAKO_white_adipose_3months_replicate2
3.000
white adipose
DAKO_brown_adipose_3months_replicate5
3.000
brown adipose
Control_wildtype_brown_adipose_12months_replicate_3
12.000
brown adipose
Control_wildtype_brown_adipose_7months_replicate_4
7.000
brown adipose
ATGLAKO_brown_adipose_12months_replicate_2
12.000
brown adipose
ATGLAKO_white_adipose_3months_replicate_3
3.000
white adipose
Control_wildtype_white_adipose_3months_replicate_1
3.000
white adipose
HSLAKO_brown_adipose_7months_replicate2
7.000
brown adipose
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