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Accession IconSRP073099

Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis in zebrafish via cell-extrinsic signaling pathways

Organism Icon Danio rerio
Sample Icon 24 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500, NextSeq 500

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Description
Using zebrafish tet2-/-;tet3-/- mutants, we identify functions for Tet enzymes and 5-hydroxymethylcytosine (5hmC) in regulating gene expression and cell type-specific differentiation during retinal development. Overall design: RNAseq from tet2-/-;tet3-/- mutant and sibling embryonic eye tissues dissected at 72hpf and 36hpf.
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24
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