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Accession IconSRP073333

Role of COP1 on MAP kinase transcriptional output in gastrointestinal stromal tumor

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
COP1 regulates MAP kinase dependent stability Pea3 transcription factors. We determined the role of COP1 in the regulation of MAP kianse transciptional output. We transfected GIST882 cells with siRNA against a scrambled sequence and two sequences against COP1. We treated cells for 8 hours with vehicle or 100 nM PD0325901 in duplicate and isolated RNA for sequencing. Overall design: Examination of transcriptome in COP1 intact and COP1 loss GIST882 GIST cells in response to MAP kinase inhibition.
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12
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