github link
Accession IconSRP077574

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade [RNA-Seq]

Organism Icon Mus musculus
Sample Icon 29 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

Submitter Supplied Information

Description
The goal of this study is to investigate if interferon signaling regulates immune checkpoint blockade in mouse melanoma model. Overall design: Transcription profiling for B16, B16 after chronic interferon treatment, B16 derived checkpoint blockade resistant strain 499 and various knockout from 499, coupled with ATA-seq data.
PubMed ID
Total Samples
29
Submitter’s Institution
No associated institution

Samples

Show of 29 Total Samples
Filter
Add/Remove
Accession Code
Title
Specimen part
Treatment
Subject
Processing Information
Additional Metadata
RNA_B16_NT_2
cd45 negative tumor cells
none
sorted b16 melanoma cells
NA
RNA_499_cas9_3
cd45 negative tumor cells
none
sorted 499 resistant cells with cas9
NA
RNA_499_CRISPR_1
cd45 negative tumor cells
none
sorted 499 crispr control cells
NA
RNA_499_IFNGRKO_1
cd45 negative tumor cells
none
sorted 499 ifngr crispr ko cells
NA
RNA_499_IFNGRKO_2
cd45 negative tumor cells
none
sorted 499 ifngr crispr ko cells
NA
RNA_B16_IFNy_2
cd45 negative tumor cells
2 week chronic ifny treatment before mouse injection
sorted b16 melanoma cells after chronic ifny treatment
NA
RNA_499_cas9_1
cd45 negative tumor cells
none
sorted 499 resistant cells with cas9
NA
RNA_499_AGKO_6
cd45 negative tumor cells
none
sorted 499 ifnar and ifngr crispr ko cells
NA
RNA_499_CRISPR_4
cd45 negative tumor cells
none
sorted 499 crispr control cells
NA
RNA_499_STAT1_KO_1
cd45 negative tumor cells
none
sorted 499 stat1 crispr ko cells
NA
Loading...