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Accession IconSRP131032

Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3

Organism Icon Mus musculus
Sample Icon 5 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss. Overall design: RNA sequencing in SV40T immortalized SIRT3 WT (triplicates) and SIRT3 KO MEF (duplicates) lines under normal conditions.
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5
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