Single-cell sequencing of JMJD1C Jumonji domain mutated MLL-AF9 Leukemia cells

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SRP192686

Mus musculus

8 Downloadable Samples

NextSeq 500

Submitter Supplied Information

Description

We performed single-cell sequencing on mouse MLL-AF9-cas9 leukemia cells 7 days after transduction with sgRNA against Renilla or JMJD1C JmjC domain. We revealed heterogeneity within each population. Overall design: We performed single-cell sequencing on mouse MLL-AF9 cells harboring JMJD1C sgRNA targeting jumonji domain or renilla control sgRNA.

PubMed ID

31076406

Publication Title

Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia.

Total Samples

Submitter’s Institution

No associated institution

Authors

Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson KS, Rao S, Wang D, Zhu N

Source Repository

Sequence Read Archive (SRA)

No rows found