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GSE27329
Mus musculus
24 Downloadable Samples
Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
Background: Cardiac transcription factors are master regulators during heart development. Recently, some were shown to transdifferentiate noncardiac mesoderm cells and cardiac fibroblasts into cardiomyocytes. However, the individual roles of each transcription factors in activating cardiac gene program have not been elucidated. We examined cardiac-specific and genome-wide gene expression in fibroblasts induced with cardiac transcription factors Nkx2.5 (N), Tbx5 (T), Gata4 (G), Myocardin (M) alone or different combinations.
Publication Title
Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.
Sample Metadata Fields
Cell line
View Samples- Homo sapiens
- 139 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Homo sapiens
- 42 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
Accounting for transcriptional features of endurance adaptations to training is important and could help elucidate the high variability in oxygen uptake (VO2) response. We aimed to identify whole-transcriptome signatures of an endurance training protocol in whole-blood (leukocytes), PBMCs and skeletal muscle tissue of the same group of individuals in a controlled environment.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Homo sapiens
- 39 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
Accounting for transcriptional features of endurance adaptations to training is important and could help elucidate the high variability in oxygen uptake (VO2) response. We aimed to identify whole-transcriptome signatures of an endurance training protocol in whole-blood (leukocytes), PBMCs and skeletal muscle tissue of the same group of individuals in a controlled environment.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Homo sapiens
- 40 Downloadable Samples
- Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
There is high variability in responses to drug therapy for hypertension. Gene expression may help enlighten molecular mechanisms of genome control underlying pathophysiology.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Race
View Samples- Homo sapiens
- 38 Downloadable Samples
- Affymetrix Human Genome U133A Array (hgu133a)
Description
19 paired human left ventricular apex samples were harvested at the time of implant of a left ventricular assist device (PRE) and at the time of explant (POST). The cohort included patients that were clinically classified as "ischemic" (I) showing evidence of coronary artery disease, "non-ischemic" (N) no evidence of coronary artery disease or "acute Myocardial infarction" (IM) myocardial infarction within 10 days of the implant. Tissue was processed and hybridized to the Affymetrix HG-U133A chip.
Publication Title
Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks.
Sample Metadata Fields
No sample metadata fields
View Samples- Homo sapiens
- 32 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
Accounting for transcriptional features of endurance adaptations to training is important and could help elucidate the high variability in oxygen uptake (VO2) response. We aimed to identify whole-transcriptome signatures of an endurance training protocol in whole-blood (leukocytes), PBMCs and skeletal muscle tissue of the same group of individuals in a controlled environment.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Homo sapiens
- 26 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
Accounting for transcriptional features of endurance adaptations to training is important and could help elucidate the high variability in oxygen uptake (VO2) response. We aimed to identify whole-transcriptome signatures of an endurance training protocol in whole-blood (leukocytes), PBMCs and skeletal muscle tissue of the same group of individuals in a controlled environment.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Homo sapiens
- 26 Downloadable Samples
- Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
There is an association between transcriptome and the exercise-related phenotype. Peripheral blood cells suffer alterations in the gene expression pattern in response to perturbations caused by exercise. The acute response to endurance activates stress and inflammation, as well as growth and tissue repair responses.
Publication Title
PBMCs express a transcriptome signature predictor of oxygen uptake responsiveness to endurance exercise training in men.
Sample Metadata Fields
Sex, Specimen part, Disease, Disease stage, Treatment, Subject, Time
View Samples- Rattus norvegicus
- 24 Downloadable Samples
- Affymetrix Rat Genome 230 2.0 Array (rat2302)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
Sample Metadata Fields
No sample metadata fields
View Samples