Association of juvenile spondyloarthritis (jSpA) with the HLA-B27 genotype is well established, but there is little knowledge of other genetic factors with a role in disease development. The aim of the present study was to identify and confirm gene signatures and novel biomarkers in various cohorts of untreated and treated patients diagnosed with jSpA and other forms of juvenile idiopathic arthritis (JIA).
Aberrant expression of shared master-key genes contributes to the immunopathogenesis in patients with juvenile spondyloarthritis.
Sex, Specimen part, Disease
View SamplesThe aim of the present study was to identify and confirm gene expression differences in control H4 cells and WT asyn expressing H4 cells, one of the cell-based models of Parkinson`s disease. DNA microarray gene expression was performed in two samples of control H4 cells and in two samples expressing WT asyn, along with bioinformatics analysis of retrieved data.
No associated publication
Specimen part
View Sampleswe aimed to explore the potential therapeutic effects of human mesenchymal stem cell on severe liver disease
No associated publication
Sex, Specimen part, Cell line
View SamplesAnalyze of RNA expression of Old Fibroblast and Young Fibroblast. Compare RNA expression of Old Fibroblast to RNA expression of Young Fbroblast
No associated publication
Sex, Specimen part
View Sampleswe analysis of sham fibroblast and UVA fibroblast RNA expression using RNA sequencing and compare RNA expression.
No associated publication
Sex, Specimen part
View SamplesWe generate miR-25 KO mice by Cas-9 technology, and run 5 month kidney RNA sequencing.
No associated publication
Sex, Specimen part, Cell line
View SamplesAdult neural stem cells derived from wild type and Sirt1 conditional knockout mice were treated with or without X-ray, the total RNA extracted from these cells were used for RNA sequencing.
No associated publication
Sex, Age, Specimen part, Cell line
View SamplesNo description.
No associated publication
Sex, Age, Specimen part
View SamplesIdiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial disease of unknown cause. It remains impractical to conduct early diagnosis and predict IPF progression just based on gene expression information. Moreover, the relationship between gene expression and quantitative phenotypic value in IPF keeps controversial. To identify biomarkers to predict survival in IPF, we profiled protein-coding gene expression in peripheral blood mononuclear cells (PBMCs). We linked the gene expression level with the quantitative phenotypic variation in IPF, including diffusing capacity of the lung for carbon monoxide (DLCO) and forced vital capacity (FVC) percent predicted. In silico analyses on the expression profiles and quantitative phenotypic data allowed for the generation of a set of IPF molecular signature that predicted survival of IPF effectively.
Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.
Sex, Age, Disease, Race
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.
Age, Specimen part
View Samples