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GSE73800
Mus musculus
120 Downloadable Samples
Illumina MouseWG-6 v2.0 expression beadchip
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Compound, Time
View Samples- Mus musculus
- 108 Downloadable Samples
- Illumina mouse-6 v1.1 expression beadchip
Description
In summary, we characterized genomic signatures of response to drugs of abuse and we found positive correlations between the drug-induced expression and various behavioral effects. These signatures are formed by two dynamically inducible transcriptional networks: (1) CREB/SRF-dependent gene pattern that appears to be related to drug-induced neuronal activity, (2) the pattern of genes controlled at least in part via release of glucocorticoids and androgens that are associated with rewarding and harmful drug effects. The discovery of co-expressed networks of genes allowed for the identification of master-switch controlling factors involved in molecular response to the drugs. Finally, using the pharmacological tools we were able to dissect and inhibit particular gene expression patterns from genomic profile.
Publication Title
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.
Sample Metadata Fields
Compound, Time
View Samples- Mus musculus
- 78 Downloadable Samples
- Illumina MouseWG-6 v2.0 expression beadchip
Description
To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and after 13, 15, 18 or 24 days of withdrawal.
Publication Title
Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine.
Sample Metadata Fields
Specimen part, Compound
View Samples- Mus musculus
- 60 Downloadable Samples
- Illumina MouseWG-6 v2.0 expression beadchip
Description
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyclidine and memantine.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Compound, Time
View Samples- Mus musculus
- 60 Downloadable Samples
- Illumina MouseWG-6 v2.0 expression beadchip
Description
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyclidine and memantine.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Compound, Time
View Samples- Rattus norvegicus
- 50 Downloadable Samples
- Affymetrix Rat Gene 2.1 ST Array (ragene21st)
Description
Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention. The different stages of disease progression are described by the complex pattern of transcriptional regulations. The dynamics in pattern alterations were monitored in each individual animal during the time-course of OA progression.
Publication Title
Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis.
Sample Metadata Fields
Treatment
View Samples- Mus musculus
- 48 Downloadable Samples
- Illumina MouseWG-6 v2.0 R2 expression beadchip
Description
We utilized whole-genome microarrays (Illumina Mouse WG-6) to measure changes in mRNA abundance levels induced by steroid hormones in primary neurons and astrocytes. To stimulate gene expression we treated neuronal and astroglial cultures with glucocorticoid receptor agonist (dexamethasone), mineralocorticoid (aldosterone), progesterone (progesterone), androgen (5-dihydrotestosterone) and estrogen 2 (-estradiol).
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Treatment
View Samples- Mus musculus
- 36 Downloadable Samples
- Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug.
Publication Title
Morphine effects on striatal transcriptome in mice.
Sample Metadata Fields
No sample metadata fields
View Samples- Homo sapiens
- 32 Downloadable Samples
- Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
Differences between groups of children with obesity and healthy controls.
Publication Title
Looking for new diagnostic tools and biomarkers of hypertension in obese pediatric patients.
Sample Metadata Fields
Specimen part, Disease
View Samples- Mus musculus
- 30 Downloadable Samples
- Illumina MouseWG-6 v2.0 R2 expression beadchip
Description
We have aimed to analyze dexamethasone-induced transcriptional profiling in astrocytes and neurons of the mouse nucleus accumbens (NAc).
Publication Title
No associated publication
Sample Metadata Fields
Specimen part
View Samples