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refine.bio helps you build ready-to-use datasets with normalized transcriptome data from all of the world’s genetic databases.
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accession-icon GSE66646
Expression data from ethanol and saline exposed mice
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure.

Sample Metadata Fields

Sex, Specimen part, Treatment

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accession-icon GSE12885
Genome-wide changes in DNA methylation and copy number play a role in deregulation of gene expression in osteosarcoma
  • organism-icon Homo sapiens
  • sample-icon 14 Downloadable Samples
  • Technology Badge IconAgilent-014693 Human Genome CGH Microarray 244A (Feature number version), Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

Sample Metadata Fields

Specimen part

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accession-icon GSE11416
Comparison of osteosarcoma cell lines and normal human osteoblasts
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconAgilent-014693 Human Genome CGH Microarray 244A (Feature number version), Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

In vitro analysis of integrated global high-resolution DNA methylation profiling with genomic imbalance and gene expression in osteosarcoma.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE12865
Gene expression of human paediatric osteosarcoma tumour samples relative to normal human osteoblasts
  • organism-icon Homo sapiens
  • sample-icon 14 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions.

Publication Title

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

Sample Metadata Fields

Specimen part

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accession-icon GSE11414
Gene expression of osteosarcoma cell (U2OS, MG63) lines relative to normal human osteoblasts (HOB)
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions.

Publication Title

In vitro analysis of integrated global high-resolution DNA methylation profiling with genomic imbalance and gene expression in osteosarcoma.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE85573
Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes
  • organism-icon Homo sapiens
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Treatment, Race

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accession-icon GSE66175
Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification
  • organism-icon Homo sapiens
  • sample-icon 479 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Description

The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation.

Publication Title

Importance of substantial weight loss for altering gene expression during cardiovascular lifestyle modification.

Sample Metadata Fields

Sex, Age, Specimen part

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accession-icon GSE78958
Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis of 405 tumors by BMI
  • organism-icon Homo sapiens
  • sample-icon 424 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Description

Background: Obesity is a risk factor for breast cancer in postmenopausal women and is associated with decreased survival and less favorable clinical characteristics such as greater tumor burden, higher grade, and poor prognosis, regardless of menopausal status. Despite the negative impact of obesity on clinical outcome, molecular mechanisms through which excess adiposity influences breast cancer etiology are not well-defined.

Publication Title

Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients.

Sample Metadata Fields

Disease stage

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accession-icon GSE46097
Expression data of Participants of Ornish intervention and Control group
  • organism-icon Homo sapiens
  • sample-icon 377 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Description

Intensive lifestyle modification is believed to mediate cardiovascular disease (CVD) risk through traditional pathways that affect endothelial function and progression of atherosclerosis; however, the extent, persistence, and clinical significance of molecular change during lifestyle modification are not well known. Our study reveals that gene expression signatures are significantly modulated by rigorous lifestyle behaviors and track with CVD risk profiles over time.

Publication Title

Intensive cardiovascular risk reduction induces sustainable changes in expression of genes and pathways important to vascular function.

Sample Metadata Fields

Sex, Age

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accession-icon GSE48931
Master regulators of FGFR2 signalling and breast cancer risk
  • organism-icon Homo sapiens
  • sample-icon 260 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Master regulators of FGFR2 signalling and breast cancer risk.

Sample Metadata Fields

Specimen part, Cell line

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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